In the time of Saladin al-Ayoubi, approximately 1187 AD, his army took over Jenin. It was also important during the 13th century because the Mamluks, who feared Crusader invasions, destroyed coastal Palestinian towns and fortified several inland cities, including Jenin.
During the World War II, the Germans built an airport runway in Jenin to help the Turks.
The fifth holiest Christian place and the third oldest church in the world is located in the village of Burqin, 3 kms west of Jenin. The Burqin church is also known as St. George's church.